UCL PET/MR Methods Symposium

21-23 September 2016

The symposium was held at Birkbeck, University of London, Lecture Theatre B-01, Clore Management Centre, Malet Street, London WC1E 7HX

Organisers: Brian Hutton, Kris Thielemans, David Atkinson, Simon Arridge, Sébastien Ourselin
Sponsored by: UCL EPSRC PET/MRI and CCP PET-MR grants

Focus of the workshop

This workshop focused on development of analysis methods for PET/MRI with the following objectives:
•    To present relevant current research at UCL and other centres
•    To provide a forum for networking and future planning
•    To encourage national collaboration on PET/MRI methods

Invited speakers included: Martin Burger (Munster), Gaspar Delso (Cambridge), Marc Kachelriess (Heidelberg), Thomas Kuestner (Stuttgart), Ian Law (Copenhagen), Julian Matthews (Manchester), Steven Sourbron (Leeds), Claudia Prieto Vasquez (KCL) as well as PhD students and research fellows from UCL, KCL, KU Leuven, Julich and Imanova.

The speakers have kindly agreed to make the slides from their presentations available here under the Creative Commons "Attribution-NoDerivs" license. Please respect the terms of this license. Some unpublished data has been removed from a few of the presentations.

Wednesday

Session 1: National networking initiatives   Chair: B Hutton

• Roger Gunn (Imanova) Dementia platform: methods.
• Sebastien Ourselin (UCL) Dementia platform: data management.
• Kris Thielemans (UCL) CCP: national network on PET and MR reconstruction.
• John Dickson (UCH/UCL) PET/MR harmonisation for multi-centre studies.

Session 2: Attenuation correction   Chair: S Ourselin

• Gaspar Delso (Zurich) PET/MR attenuation correction based on short echo-time sequences
• Ahmad Rezaei (Leuven) Joint estimation of activity and attenuation in TOF-PET.
• Ninon Burgos (UCL) Image synthesis for the attenuation correction of PET/MR Data
• Martin Belzunce (KCL) High accuracy brain PET image reconstruction for the mMR using GATE and a composite system model

Thursday

Session 1: Motion correction 1   Chair: D Atkinson

• Thomas Kuestner (Stuttgart) Respiratory and cardiac PET/MR motion correction for application in clinical practice.
• Ottavia Bertolli (UCL) Detecting motion from the data.
• Jamie McClelland (UCL) A generalised framework combining image registration, respiratory motion modelling, and motion compensated image reconstruction
• Richard Manber (UCL) Joint PET MR respiratory motion models for clinical PET motion correction.

Session 2: Kinetic modelling 1   Chair: A Barnes

• Steven Sourbron (Leeds) Tracer kinetic analysis in Dynamic Contrast Enhanced MRI
• David Thomas (UCL) Measuring cerebral blood flow and other haemodynamic parameters using Arterial Spin Labelling MRI.
• Catherine Scott (UCL) ASL-incorporated pharmacokinetic modelling of Amyloid PET data with reduced acquisition time.
• Alex Whittington (Imanova) Spatiotemporal modelling of misfolded proteins in neurodegenerative diseases

Session 3: Reconstruction   Chair: K Thielemans

• Claudia Prieto Vasquez (KCL) Under-sampled reconstruction techniques to speed up MRI acquisition.
• Andrew Reader (KCL) Multi-parametric MRI-guided PET image reconstruction.
• Pawel Markiewicz (UCL) Uniform acquisition modelling across PET imaging systems for robust statistical analysis
• Debora Salvado (UCL) INSERT: challenges in developing SPECT/MRI

Session 4: Motion correction 2   Chair: T Kuestner

• Marc Kachelriess (Heidelberg) Motion compensation, from CT to MR to PET
• Phil Noonan (Imanova) Motion tracking and correction for PET/MRI using external cameras
• Daniel Balfour (KCL) Reduced Parameter Motion/Activity Estimation in PET Using Parameterised Motion Models
• Alexandre Bousse (UCL) Direct motion compensation in attenuation corrected PET reconstruction

Friday

Session 1: Joint reconstruction   Chair: S Arridge

• Julian Rasch (Munster) Joint PET-MR Reconstruction via coupled Bregman Iterations
• Georg Schramm (Leuven) PET reconstruction with convex gradient-based anatomical priors
• Matthias Ehrhardt (Cambridge) Combined image reconstruction for combined PET-MR imaging.
• Abolfazl Mehranian (KCL) Non-convex joint-sparsity regularization for synergistic PET and SENSE MRI reconstruction.

Session 2: Kinetic modelling 2   Chair: R Gunn

• Julian Matthews(Manchester) Challenges in tracer kinetic modelling
• Kjell Erlandsson (UCL) Improved kinetic modelling with cross-modality parameter coupling
• Hasan Sari (UCL) Blood free modelling of PET tracers using MR-corrected IDIFs.
• Liliana Caldeira (Julich) Simultaneous Acquisition of Dynamic PET-MRI: Arterial Input Function using DSC-MRI and [18F]-FET

Session 3: Clinical considerations   Chair: P Marsden

• Ian Law (Copenhagen) Clinical Brain PET/MRI
• Anna Barnes (UCH/UCL) The boundaries of simultaneousMRI and PET: what you can and can't do with MRI while collecting PET data.
• Elisabetta Grecchi (KCL) Multimodal-multiresolution partial volume correction - a clinical application
• Isabel Dregely (KCL) PET/MR in prostate cancer